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Pro-Stat^® AWC

Many patients in long-term health care facilities develop pressure ulcers, or bed sores.1, 2 The Agency for Health Care Policy and Research's (AHCPR) guidelines for Treatment of Pressure Ulcers indicate that patients with pressure ulcers need 30 to 35 kilocalories and 1.25 to 1.5 grams of protein per kilogram of body weight daily, and increased requirements for L-Arginine, L-Cystine, Vitamin C, and Zinc 3. Pro-Stat® Advanced Wound Care is a high calorie, complete protein liquid, with added Arginine, Cystine, Zinc, and Vitamin C.

Pro-Stat® AWC liquid protein formula is an enzyme- hydrolyzed concentrated protein fortified with L-tryptophan. Per serving, Pro-Stat® AWC has 17 grams of protein and 108 k/cal per 30 ml (one ounce) with added L-arginine, zinc and vitamin C. This provides the necessary nutrients needed to accelerate wound healing in one convenient low-volume dose.

Each one fluid ounce (30 ml) serving of Pro-Stat AWC contains:

Protein

17 grams of hydrolyzed complete protein to reduce protein energy/calorie malnutrition, build muscle, repair tissue, fight infections and reduce overall morbidity/mortality. Indicated for pressure ulcers, burns, post-surgical wounds, diabetic foot ulcers, and venous stasis ulcers.

Arginine

The physiological demands of repair and recovery from wounds, burns, sepsis and trauma (including surgical trauma) often require greater amounts of L-arginine than can be synthesized by the body. Additional dietary intake of L-arginine is indicated when these conditions are present.

• Needed to promote protein regeneration and the healing of wounds.⁴
• Essential when the body is under stress or in an injured state.⁵
• Conditionally essential, particularly during growth, illness or metabolic stress when the body’s production may be insufficient to meet demands.⁶
• Improves markers of wound healing with greater protein and hydroxyproline in the wound bed and promotion of positive nitrogen balance.⁷

Cystine

Cystine controls and promotes positive nitrogen balance for minimizing muscle breakdown and rebuilding lean body mass (LBM).

• Required to synthesize glutathione ( GSH ), the cell’s major antioxidant that plays a vital role during tissue repair and collagen synthesis.
• GSH destroys damaging oxygen radicals that are continually being generated with pressure ulcers and GSH keeps Vitamin C stable and active.
• Cystine produces the bioavailable form of GSH.

Ascorbic Acid (Vitamin C)

Vitamin C is essential for wound healing and for the repair and maintenance of cartilage, bones, and teeth. Vitamin C deficiency can lead to a decreased wound-healing rate. The body does not manufacture vitamin C on its own, nor does it store it.^8,9

• Promotes collagen synthesis and enhances activation of leukocytes and macrophages to the wound site.⁹
• Promotes healthy cell development, proper calcium absorption, normal tissue growth and repair - such as healing of wounds and burns.⁹
• Required for the growth and repair of tissues in all parts of the body.⁹
• Necessary to form collagen, an important protein used to make skin, scar tissue, tendons, ligaments, and blood vessels.⁹

Zinc

Zinc has been shown to be beneficial to wound healing and zinc deficiency has been associated with delayed wound healing.^10,11

• Assists in immune function and interacts with platelets in blood clotting.¹²
• When zinc supplements are given to individuals with low zinc levels, the numbers of T-cell lymphocytes circulating in the blood increase and the ability of lymphocytes to fight infection improves.¹²

1. Michocki RJ, Lamy PP. The problem of pressure sores in a nursing home population: statistical data. J AM Geriatr Soc. 1976; 24:323-328.
2. Gilmore S, Robinson G, Posthauer M, Raymond J. Clinical indicators associated with unintentional weight loss and pressure elderly resident of nursing facilities. J Am Diet Assoc 1995; 95(9):984-92.
3. Bergstron N, Bennett MA, Carlson CE, et al. Treatment of pressure ulcers. Clinical Practice Guideline, No. 15. AHCPR Publication No. 95-0652. Rockville, Md.: Agency for Health Care Policy and Research. December 1994. NPUAP Website: http//npuap.org/stagingdefinition.htm.
4. Kirk SJ, Hurson M, Regan M, et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 1993;114:155-160.
5. Barbul A, Lazarou SA, Efron DT, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990;108:331-337.
6. Benati G, Delvecchio S, Cilla D, et al. Impact on pressure ulcer healing of an arginine enriched nutritional solution in patients with severe cognitive impairment. Arch Gerontol Geriatr. 2001; 7(suppl): 43-47.
7. Albina JE, Mills CD, Barbul A, et al. Arginine metabolism in wounds. Am J Physiology 1988;254:E459-E467
8. W. M. Ringsdorf, Jr and E Cheraskin, "Vitamin C and Human Wound Healing" Oral Surg Oral Med Oral Pathol, 53(3), March 1982, p.231 - 236.
9. http://www.nlm.nih.gov/medlineplus/ency/article/002404.htm
10. Adv Wound Care. 1999 Apr;12(3):137-8. The role of zinc in wound healing. Andrews M, Gallagher-Allred C. Geriatric and Long Term Care Services, Ross Products Division, Abbott Laboratories, Columbus, OH, USA.
11. Anderson I. Zinc as an aid to healing. Nurs Times 1995;91:68, 70.
12. http://ods.od.nih.gov/factsheets/cc/zinc.html#issues